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KMID : 1149220100180020215
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 2 p.215 ~ p.225
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Effects of Lycii Radicis Cortex in HPA-Axis System on the Forced Swimming Test
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Koo Beom-Mo
Lee Tae-Hee
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Abstract
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In order to investigate the antidepressant effects of Lycii Radicis Cortex on the change of HPA-Axis system, the forced swimming test was performed. The expressions of CRF and c-Fos in the PVN were measured with immunohistochemical method and the concentration of ACTH in Serum was evaluated with ELISA method. And the results obtained were as follows. Results : 1. The duration of immobility in the forced swimming test was significantly decreased in the LRC100 group and the LRC400 group(P<0.001). 2. The expressions of CRF and c-Fos were significantly reduced in the LRC100 group and the LRC400 group(P<0.001). And the concentration of ACTH in Serum were significantly reduced in the LRC 100 group(P<0.05). According to the results above mentioned, it can be considered that Lycii Radicis Cortex has antidepressant effects.
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KEYWORD
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Lycii Radicis Cortex, FST, CRF, c-Fos, ACTH, HPA-Axis, antidepressant
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